Dr. K.W. CHEUNG 張嘉宏醫生

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Clinical Associate Professor

MBBS; MD (HK); MRCOG; FHKCOG; FHKAM (O&G)
location Department of O&G, Queen Mary Hospital
phone (852)-2255-4517
fax (852)-2855-0947
email https://orcid.org/0000-0003-1207-6494
Research Interests
  • Prevention of preterm birth
  • Hepatitis B in pregnancy
  • Stillbirth
Publications
2024
2023
2022
  • Cheung KW, Seto MTY, Wang W, Ng CT, To WWK, Ng EHY. Trend and causes of maternal death, stillbirth and neonatal death over seven decades in Hong Kong. Lancet Reg Health West Pac. 2022 Jul 6;26:100523. doi: 10.1016/j.lanwpc.2022.100523. PMID: 35833208; PMCID: PMC9272372.
  • FERNANDO T.S.R., CHEN X., Cheng K.W., Wong B.P.C., Qi S., Jiang L., Kodithuwakku Kankanamge S.P.K., Ng E.H.Y., Yeung W.S.B. and Lee C.K.F., ACE inhibitors on ACE1, ACE2, and TMPRSS2 expression and spheroid attachment on human endometrial Ishikawa cells, Reproductive Biology. 2022, 22, 100666.
  • Cheung K.W., Bonet M., Frank K.A., Oladapo O.T., Hofmeyr G.J., Ciabati L., De Oliveira L.L., Souza R., Browne J., Rijken M., Fawcus S., Hofmeyr J., Liabsuetrakul T., Gülümser Ç., Blennerhassett A., Lissauer D., Meher S., Althabe F., Bonet M., Metin Gülmezoglu A. and Oladapo O., Clinical algorithms for management of fetal heart rate abnormalities during labour, BJOG: An International Journal of Obstetrics & Gynaecology. 2022.
  • Cheung K.W., Tan L.N., Meher S., Ciabati L., Oliveira L.L.D., Souza R., Browne J., Rijken M., Fawcus S., Hofmeyr J., Liabsuetrakul T., GÜLÜMSER Ç., Blennerhassett A., Lissauer D., Meher S., Althabe F., Bonet M., Metin Gülmezoglu A. and Oladapo O., Clinical algorithms for the management of intrapartum maternal urine abnormalities, BJOG: An International Journal of Obstetrics & Gynaecology. 2022.
  • Cheung K.W., Seto T.Y.M., Wang W., Mok Y.K.S. and Cheung V.Y.T., Clinical presentation, investigation, underlying causes, and subsequent pregnancy outcomes among different phenotypes of second trimester miscarriage, Journal of Obstetrics and Gynaecology Research. 2022. http://dx.doi.org/10.1111/jog.15514
  • Lai H.T.T., Kwok S.T.G., Wang W., Seto T.Y.M. and Cheung K.W., Fear of childbirth: Validation study of the Chinese version of Wijma delivery expectancy / experience questionnaire version B, Midwifery. 2022, 108, 103296.
  • Lee CL, Chen Z, Zhang Q, Guo Y, Ng VWY, Zhang B, Bai K, Ruan D, Kan ASY, Cheung KW, Mak ASL, Yeung WSB, Su R, Yang Q, Chen M, Du MR, Jian Z, Fan X, Chiu PCN. Dysregulation of the CD147 complex confers defective placental development: A pathogenesis of early-onset preeclampsia. Clin Transl Med. 2022 Jun;12(6):e826. doi: 10.1002/ctm2.826
  • Lai H.T.T., Kwok S.T.G., Wang W., Seto T.Y.M. and Cheung K.W., Fear of childbirth: Validation study of the Chinese version of Wijma delivery expectancy/experience questionnaire version A, Midwifery. 2022, 104, 103188.
  • BAI K., Lee C.L., Liu X., LI J., Cao D., Zhang L., Hu D., Li H., Hou Y., Xu Y., Kan S.Y.A., Cheung K.W., Ng E.H.Y., Yeung W.S.B. and Chiu C.N., Human placental exosomes induce maternal systemic immune tolerance by reprogramming circulating monocytes, Journal of Nanobiotechnology. 2022, 20.
  • Ting Y.H., So P.L., Cheung K.W., Lo T.K., Ma T. and Leung T.Y., Non-visualisation of fetal gallbladder in a Chinese cohort, Hong Kong Medical Journal. 2022.
  • Liu Z, Zhai M, Zhang Q, Yang T, Wan Z, Li J, Liu X, Xu B, Du L, Chan RWS, Zhang L, Yeung WSB, Cheung KW, Chiu PCN, Wang WJ, Lee CL, Gao Y. Resolving the gene expression maps of human first-trimester chorionic villi with spatial transcriptome. Front Cell Dev Biol. 2022 Dec 6;10:1060298. doi: 10.3389/fcell.2022.1060298.
  • Mok Y.K.S., Cheung K.W., Wang W., Li R.H.W., Shek W.M.N. and Ng E.H.Y., The effects of not having continuous companion support during labour on pregnancy and neonatal outcomes during the COVID-19 pandemic, Midwifery. 2022, 108, 103293.
  • PW Hui, Mimi TY Seto and KW Cheung. Behavioural adaptations and responses to obstetric care among pregnant women during an early stage of the COVID-19 pandemic in Hong Kong: a cross-sectional survey. Hong Kong Med J 2022, Oct;28(5):367-75 | Epub 1 Aug 2022. https://doi.org/10.12809/hkmj209032
2021
  • Hui P.W., Seto T.Y.M. and Cheung K.W., Combined interstitial laser cauterisation of placental anastomosis and intrauterine intracardiac transfusion following monochorionic co-twin demise: a case report, Hong Kong Medical Journal. 2021, 27, 293-296. http://dx.doi.org/10.12809/hkmj208806
  • FERNANDO T.S.R., Kottawatta K.S.A., JIANG L., CHEN X., Cheng K.W., Wong B.P.C., Ng E.H.Y., Yeung W.S.B. and Lee C.K.F., Differential expression of protein disulfide isomerase (PDI) in regulating endometrial receptivity in humans, Reproductive Biology. 2021, 21, 100498. http://dx.doi.org/10.1016/j.repbio.2021.100498
  • Fernando S.R., Lee C.L., Wong B.P.C., Cheng K.W., Lee C.Y.L., Chan M.C., Ng E.H.Y., Yeung W.S.B. and Lee C.K.F., Expression of membrane protein disulphide isomerase A1 (PDIA1) disrupt a reducing microenvironment in endometrial epithelium for embryo implantation, Experimental Cell Research. 2021, 405, 112665. http://dx.doi.org/10.1016/j.yexcr.2021.112665
  • Cheung K.W., Seto T.Y.M., Tsui P.M., So P.L., Wong D., Kong C.W., Wang W. and Ng E.H.Y., Knowledge, perception and expectation of management of hepatitis B infection among pregnant hepatitis B carriers in Hong Kong
  • Cheung K.W., Optimal Management of Pregnant Hepatitis B Carriers to Achieve Complete Eradication of Hepatitis B Infection in Hong Kong, Hong Kong Medical Diary. 2021, 26(3), 7-9.
  • Mok Y.K.S., Seto T.Y.M., Lai H.T.T., Wang W. and Cheung K.W., Pitfalls of International Classification of Diseases – Perinatal mortality in analysing stillbirths, Public Health. 2021, 201, 12-18. http://dx.doi.org/10.1016/j.puhe.2021.09.032
  • Hui P.W., Seto T.Y.M. and Cheung K.W., Postnatal depression scores and maternal characteristics during COVID-19 pandemic, BJOG 2021, Special Issue: Top Scoring Abstracts of the RCOG Virtual World Congress 2021. 128, 185-213. http://dx.doi.org/10.1111/1471-0528.15_16715
  • Seto MT, Bertoli-Avella AM, Cheung KW, Chan KY, Yeung KS, Fung JL, Beetz C, Bauer P, Luk HM, Lo IF, Lee CP, Chung BH, Kan AS. Prenatal and postnatal diagnosis of Schuurs-Hoeijmakers syndrome: Case series and review of the literature. Am J Med Genet A. 2021 Feb;185(2):384-389.
  • So P.L., Luk H.M., Cheung K.W., Hui W., Chung M.Y., Mak S.L.A., Lok W.Y., Yu K.P.T., Cheng S.S.W., Hau E.W.L., Ho S., Lam S.T.S. and Lo I.F.M., Prenatal phenotype of Kabuki syndrome: A case series and literature review, Prenatal Diagnosis. 2021, 41, 1089-1100. http://dx.doi.org/10.1002/pd.5998
  • Seto T.Y.M. and Cheung K.W., Prevention of maternal-to-child transmission of hepatitis B: a narrative review, Hong Kong Journal of Gynaecology, Obstetrics and Midwifery. 2021, 21, 49-52. http://dx.doi.org/10.12809/hkjgom.21.1.07
  • Poon L.C., Leung B.W., Ma T., Yu F.N.Y., Kong C.W., Lo T.K., So P.L., Leung W.C., Shu W., Cheung K.W., Moungmaithong S. and Wang C.C., Relationship between viral load, infection‐to‐delivery interval and mother‐to‐child transfer of anti‐SARS‐CoV ‐2 antibodies , Ultrasound in Obstetrics & Gynecology. 2021, 57, 974-978. http://dx.doi.org/10.1002/uog.23639
  • Chan M.K.D., Cheung K.W., Ko K.Y.J., Yung S.F.S., Lai S.F., Lam M.T., Ng Y.T.D., Lee V.C.Y., Li R.H.W. and Ng E.H.Y., Use of oral progestogen in women with threatened miscarriage in the first trimester: a randomized double-blind controlled trial, Human Reproduction. 2021, 36, 587-595. http://dx.doi.org/10.1093/humrep/deaa327
2020
  • Cheung KW, Seto MTY, Kan ASY, Wong D, Kou TKO, So PL, Lau WL, Wong RMS, Lee CP, Ng EHY. Maternal and obstetric factors of hepatitis B immunisation failure in Hong Kong: a multicentre prospective study: abridged secondary publication. Hong Kong Med J. 2020 Dec;26 Suppl 6(6):24-25.
2019

  • Cheung K.W., Morris R.K. and Kilby M.D., Congenital urinary tract obstruction, Best Practice & Research Clinical Obstetrics & Gynaecology. 2019, 58, 78-92. http://dx.doi.org/10.1016/j.bpobgyn.2019.01.003

  • Cheung K.W., Seto T.Y.M. and Kilby M.D., Delayed interval delivery when the presenting fetus is in breech presentation, American Journal of Obstetrics and Gynecology. 2019. http://dx.doi.org/10.1016/j.ajog.2019.09.030

  • Cheung K.W., Seto T.Y.M., Wang W., Lai W.S.C., Kilby M.D. and Ng E.H.Y., Effect of delayed interval delivery of remaining fetus(es) in multiple pregnancies on survival: a systematic review and meta-analysis, American Journal of Obstetrics and Gynecology. 2019. http://dx.doi.org/10.1016/j.ajog.2019.07.046

  • Cheung K.W., Seto T.Y.M., So P.L., Wong D., Mak S.L.A., Lau W.L., Wang W., Kan S.Y.A., Lee C.P. and Ng E.H.Y., Optimal timing of hepatitis B virus DNA quantification and clinical predictors for higher viral load during pregnancy, Acta Obstetricia et Gynecologica Scandinavica. 2019, 98, 1301-1306. http://dx.doi.org/10.1111/aogs.13631

  • Cheung K.W., Seto T.Y.M., Wong S., Mak S.L.A., So P.L., Lau W.L., Wang W., Kan S.Y.A., Lee C.P. and Ng E.H.Y., Pattern and predictors of medical care received by hepatitis B carriers during pregnancy and after delivery, Public Health. 2019, 168, 36-42. http://dx.doi.org/10.1016/j.puhe.2018.12.008

  • Cheung K.W., Tan L.N., Seto T.Y.M., Moholkar S., Masson G. and Kilby M.D., Prenatal Diagnosis, Management, and Outcome of Fetal Subdural Haematoma: A Case Report and Systematic Review, Fetal Diagnosis and Therapy. 2019, 1-11. http://dx.doi.org/10.1159/000496202

  • Cheung K.W., Seto T.Y.M. and Lao T.H.T., Prevention of perinatal hepatitis B virus transmission, Archives of Gynecology and Obstetrics. 2019, 300, 251-259. http://dx.doi.org/10.1007/s00404-019-05190-0

  • Cheung K.W., Seto T.Y.M., So P.L., Wong D., Mak S.L.A., Lau W.L., Lau W.L., Kan S.Y.A., Lee C.P. and Ng E.H.Y., The effect of rupture of membranes and labour on the risk of hepatitis B vertical transmission: Prospective multicentre observational study, European Journal of Obstetrics & Gynecology and Reproductive Biology. 2019, 232, 97-100. http://dx.doi.org/10.1016/j.ejogrb.2018.11.017

  • Cheung K.W., Seto T.Y.M. and Ng E.H.Y., What is the optimal timing of antiviral treatment in pregnant hepatitis B carriers with extremely high viral load?, Acta Obstetricia et Gynecologica Scandinavica. 2019. http://dx.doi.org/10.1111/aogs.13721

  • Chong H.P., Hamilton S., Mone F., Cheung K.W., Togneri F.S., Morris R.K., Quinlan-Jones E., Williams D., Allen S., McMullan D.J. and Kilby M.D., Prenatal chromosomal microarray testing of fetuses with ultrasound structural anomalies: A prospective cohort study of over 1000 consecutive cases, Prenatal Diagnosis. 2019. http://dx.doi.org/10.1002/pd.5545

  • Seto T.Y.M., Ko K.Y.J., Cheung K.W., To K.K.W., Hui P.W., Lao T.H.T. and Lee C.P., The Accuracy of Self-Screening of Group B Streptococcus in Pregnant Women—A Randomized Crossover Study, Journal of Obstetrics and Gynaecology Canada. 2019, 41, 792-797. http://dx.doi.org/10.1016/j.jogc.2018.08.003

  • Tan T.L., Cheung K.W. and Kilby M.D., Trisomy 21 and hydrops fetalis: parvovirus B19 or transient abnormal myelopoiesis?, Journal of Obstetrics and Gynaecology. 2019, 39, 556-557. http://dx.doi.org/10.1080/01443615.2018.1530740

2018

  • Cheung K.W., Lai W.S.C., MAK C.C.Y., Hui P.W., Chung B.H.Y. and Kan S.Y.A., A case of prenatal isolated talipes and 22q11.2 deletion syndrome-an important chromosomal disorder missed by noninvasive prenatal screening, Prenatal Diagnosis. 2018, 38(5): 376-378. http://dx.doi.org/10.1002/pd.5241 (Publication No. : 284917)

  • Cheung K.W., Seto T.Y.M. and Ng E.H.Y., Tenofovir to Prevent Perinatal Transmission of Hepatitis B, New England Journal of Medicine. 2018, 378: 2348-2350. http://dx.doi.org/10.1056/NEJMc1805396 (Publication No. : 293589)

  • Cheung K.W., Seto T.Y.M., Kan S.Y.A., Jalal K., Chee W.Y.Y., Wong R.M.S., Lee C.P. and Ng E.H.Y., Immunoprophylaxis Failure of Infants Born to Hepatitis B Carrier Mothers Following Routine Vaccination, Clinical Gastroenterology and Hepatology. 2018, 16: 144-145. http://dx.doi.org/10.1016/j.cgh.2017.07.013 (Publication No. : 292449)

  • Tan L.N., Cheung K.W., Philip I., Ong S. and Kilby M.D., Isolated Ascites in a Monochorionic Twin after Fetoscopic Laser Ablation Is Not Necessarily Secondary to Recurrence or Anaemia: Bowel Complications in Twin-to-Twin Transfusion Syndrome after Fetoscopic Laser Ablation, Fetal Diagnosis and Therapy. 2018, 45, 285-294. http://dx.doi.org/10.1159/000494616

2017

  • Cheung K.W., Seto M.T.Y., Kan A.S.Y., Wong D., Kou T.K.O., So P.L., Lau W.L., Jalal K., Chee Y.Y., Wong R.M.S., Lee C.P., Ng E.H.Y. (2017) Immunoprophylaxis failure of infants born to Hepatitis B carrier mothers following routine vaccination. Clin Gastroenterol Hepatol. 2017 Jul 18. pii: S1542-3565(17)30850-9. doi: 10.1016/j.cgh.2017.07.013

  • Cheung KW, Yan Seto MT, Yau Kan AS, Wong D, On Kou TK, So PL, et. al. Immunoprophylaxis Failure of Infants Born to Hepatitis B Carrier Mothers Following Routine Vaccination. Clin Gastroenterol Hepatol. 2017 Jul 18. pii: S1542-3565(17)30850-9.

  • Seto M.T.Y., Cheung K.W., Lo T.K., Ng E.H.Y., Pregnancy outcomes of women randomized to receive real versus placebo acupuncture on the day of fresh or frozen-thawed embryo transfer. Eur J Obstet Gynecol Reprod Biol. 2017 Nov;218:119-122.

2016

  • Chan DM, Cheung KW, Yung SS, Lee VC, Li RH, Ng EH. A randomized double-blind controlled trial of the use of dydrogesterone in women with threatened miscarriage in the first trimester: study protocol for a randomized controlled trial. Trials. 2016;17(1):408.

  • Cheung K.W. and Cheung V.Y.T., Pyoadenomyosis: A Rare Complication of Adenomyosis, Journal of Obstetrics and Gynaecology Canada. 2016, 38: 789.

2015

  • Cheung KW, Ngu SF and Cheung VYT. Sonographic characteristics of the uterus in asymptomatic women after second-trimester medical termination of pregnancy. J Ultrasound Med 2015, 34(4): 611-6.

2014

  • Cheung KW, Cheung VY. Hysterectomy for abnormal cervical smear when local excision is not possible. J Low Genit Tract Dis. 2014 Jul;18(3):235-9.

  • Cheung KW, Cheung VY. Recurrence of carcinoma of appendix presenting as vulvar swelling: a case report. J Obstet Gynaecol Can. 2014 Oct;36(10):904-6.

2013

  • Cheung KW, Ngu SF, Lee CP. Fetal fibronectin test on Chinese women with symptoms of preterm labour: a pilot study. Hong Kong Med J. 2013 Oct;19(5):424-8. [PubMed]

  • Cheung KW, Pun TC. Vaginal hysterectomies in patients without uterine prolapse: ten-year experience. Hong Kong Med J. 2013 Aug;19(4):323-7. [PubMed]

  • Cheung KW, Seto MT, Lee CP. Mother-to-infant transmission of hepatitis B virus infection: significance of maternal viral load and strategies for intervention. J Hepatol. 2013 Aug.

  • Cheung KW, Seto MT, Wong SF. Towards complete eradication of hepatitis B infection from perinatal transmission: review of the mechanisms of in utero infection and the use of antiviral treatment during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2013 Mar 4.

  • Cheung KW, Shek NW, Chan KH. An unusual cause of postpartum collapse: undiagnosed myasthenia gravis. J Obstet Gynaecol. 2013 Jul;33(5):528-9. [PubMed]

  • Cheung KW, Shek NW, Wong WH, Lee CP. Splenic rupture: first case of successful conservation after caesarean delivery and anticoagulation. Journal: Journal of Obstetrics and Gynaecology 2013. In press. (ID: 816664 DOI:10.3109/01443615.2013.816664)