Research Interests

• Functional genomics
• Aneuploidy
• Antibody
• Epithelial ovarian cancer

Biography:

Dr Lu holds a PhD in bioinformatics and cancer biology from the Ovarian Cancer Action Research Centre at Imperial College London, UK. Following his doctoral studies, he pursued postdoctoral training in cancer imaging and theranostics at the Imperial College Comprehensive Cancer Imaging Centre.

Research Description:

Dr Lu's research interest focuses on epithelial ovarian cancer (EOC), with a particular emphasis on ovarian clear cell carcinoma (OCCC) and high-grade serous ovarian carcinoma (HGSOC). His primary objective is to address the unmet needs in EOC by understanding the tumour evolution, tumour-microenvironment interactions, and developing antibody-based therapies.

In recent studies, Dr Lu employed integrated genomic, transcriptomic, and proteomic analyses to identify immune evasion mechanisms and a panel of membrane proteins that are enriched in EOC tumors. Specifically, He and his team have generated monoclonal antibodies (mAbs) that target these membrane proteins, and aim to further engineer them into early detection and therapeutic agents for EOC. The ongoing related projects are:

1. To understand the evolution and function of aneuploidy events in HGSOC
2. To elucidate the impact of aneuploidy on immune evasion
3. Bio-conjugation of payloads with new mechanism of action, i.e. immune-activating and imaging agents.
4. Development of immunotherapy agent via antibody engineering.
5. Discovery of mAbs specifically for OCCC.

Selected publications:

• Haonan Lu, Georg Wengert, Hantao Lou, Reema Paudel, Naina Patel, Saral Desai, Bill Crum, Kristofer Linton-Reid, Mitchell Chen, Dongyang Li, Jacey Ip, Francesco Mauri, David J Pinato, Andrea Rockall, Susan J Copley, Sadaf Ghaem-Maghami, Eric O Aboagye. Tumour and local lymphoid tissue interaction determines prognosis in high grade serous ovarian cancer. 2023 Cell Reports Medicine
• Lu Haonan, Mubarik Arshad, Andrew Thornton, Giacomo Avesani, Paula Cunnea, Ed Curry, Fahdi Kanavati, Jack Liang, Katherine Nixon, Sophie T Williams, Mona Ali Hassan, David D L Bowtell, Hani Gabra, Christina Fotopoulou, Andrea Rockall, and Eric O Aboagye. "A Mathematical-Descriptor of Tumor- Mesoscopic- Structure from Computed-Tomography Images Annotates Prognostic- and Molecular- Phenotypes of Epithelial Ovarian Cancer." Nature Communications (2019): 1-11. http://dx.doi.org/10.1038/s41467-019-08718-9.
• Lu H, Cunnea P, Nixon K, Rinne N, Aboagye EO, Fotopoulou C. Discovery of a biomarker candidate for surgical stratification in high-grade serous ovarian cancer. Br J Cancer. 2021 Mar;124(7):1286-1293. doi: 10.1038/s41416-020-01252-2. Epub 2021 Jan 21. PMID: 33473167; PMCID: PMC8007618.
• Haonan Lu; Jacob George; Mohammed Eslam; Augusto Villanueva; Luigi Bolondi; Helen L. Reeves; Misti McCain; Edward Chambers; Caroline Ward; Dewi Sartika; Caroline Sands; Lynn Maslen; Matthew R. Lewis; Ramya Ramaswami; Rohini Sharma ; Discriminatory changes in circulating metabolites as a predictor of hepatocellular cancer in patients with MAFLD, Liver Cancer, 2022, 12(1): 19-31
• Mitchell Chen, Haonan Lu, Susan J. Copley, Yidong Han, Andrew Logan, Patrizia Viola, David Pinato, Danielle Power, Eric O. Aboagye. Radiomics Can Predict Treatment Response and Pneumotoxicity from Programmed Cell Death-1 Pathway Inhibition in Non-Small Cell Lung Cancer. Journal of Thoracic Oncology. 2023

Full publication list link::

https://scholar.google.co.uk/citations?user=ZTRCrIIAAAAJ&hl=en