Dr. Erica T.Y. LEUNG 梁紫瑩博士
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Research Assistant Professor BSc (UC Davis); MMedSc; PhD (HK) |
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| Department of Obstetrics and Gynaecology (Laboratory Block) | |
| (852) 2255-4517 | |
| ericaty@hku.hk | |
| https://orcid.org/0000-0003-0510-6309 | |
Research Interests
- Advanced sperm selection
- Artificial intelligence
- Male infertility
- Sperm functions
- Sperm epigenetics
Biography:
Dr. Erica Leung received her PhD degree from the University of Hong Kong in 2022. She is currently a Research Assistant Professor in the Department of Obstetrics and Gynaecology at HKU and an Honorary Researcher at the Center for Reproductive Medicine at HKU-Shenzhen Hospital. Her primary research interests include developing advanced sperm selection techniques for clinical use and exploring the functional role of sperm miRNAs in parental inheritance.
She has authored high-impact, peer-reviewed publications in leading international journals, including Nature Reviews Urology and Human Reproduction Open. Her recent project, which utilizes deep learning to identify fertilization-competent human spermatozoa, has garnered significant media attention, including a press conference featured by HKU and coverage across various media outlets. She holds two provisional patents for cross-departmental, interdisciplinary projects developed in collaboration with industry partners, aiming to develop a highly automated deep-learning system capable of evaluating and selecting viable, high-quality spermatozoa for assisted reproduction treatments. She is also the co-founder of a startup specializing in AI-driven, high-speed imaging and microfluidic- integrated live gametes and embryo selection.
Publications
2025
- Erica T Y Leung, Xianghan Mei, Brayden K M Lee, Kevin K W Lam, Cheuk-Lun Lee, Raymond H W Li, Ernest H Y Ng, William S B Yeung, Lequan Yu, Philip C N Chiu, Automatic identification of human spermatozoa with zona pellucida-binding capability using deep learning, Human Reproduction Open, 2025;, hoaf024, https://doi.org/10.1093/hropen/hoaf024
2023
- Leung ETY, Lee BKM, Lee CL, Tian X, Lam KKW, Li RHW, Ng EHY, Yeung WSB, Ou JP, Chiu PCN. The role of spermatozoa-zona pellucida interaction in selecting fertilization-competent spermatozoa in humans. Front Endocrinol (Lausanne). 2023 Mar 20;14:1135973. doi: 10.3389/fendo.2023.1135973. PMID: 37020592; PMCID: PMC10067631.
2021
- Wang Y, Zhao W, Mei S, Chen P, Leung TY, Lee CL, Yeung WSB, Ou JP, Liang X, Chiu PCN. Identification of Sialyl-Lewis(x)-Interacting Protein on Human Spermatozoa. Front Cell Dev Biol. 2021 Jul 20;9:700396. doi: 10.3389/fcell.2021.700396. PMID: 34354992; PMCID: PMC8329450.
- Leung ETY, Lee CL, Tian X, Lam KKW, Li RHW, Ng EHY, Yeung WSB, Chiu PCN. Simulating nature in sperm selection for assisted reproduction. Nat Rev Urol. 2022 Jan;19(1):16-36. doi: 10.1038/s41585-021-00530-9. Epub 2021 Nov 5. PMID: 34741158.
2020
- Wu H, Gao J, Wang X, Leung TY, Duan YG, Chiu PCN. Platelet-activating factor induces acrosome reaction via the activation of extracellular signal-regulated kinase in human spermatozoa. Andrologia. 2020 Jun;52(5):e13565. doi: 10.1111/and.13565. Epub 2020 Mar 18. PMID: 32187723.






