Dr. Mary H.Y. TANG 唐海燕醫生

Dr. Mary H.Y. TANG hku_logo qmh_logo

Clinical Associate Professor (Part-time)


location Tsan Yuk Hospital, 30 Hospital Road, Hong Kong
phone (852)-2589-2355
fax (852)-2517-2372
email HKU Scholars Hub
email https://orcid.org/0000-0002-7507-4210
Research Interests
  • Prenatal diagnosis
  • Hui P.W., Pang P. and Tang H.Y.M., 20 years review of antenatal diagnosis of haemoglobin Bart's disease and treatment with intrauterine transfusion, Prenatal Diagnosis. 2022.
  • CHUNG C.Y., Chan Y.K., Hui P.W., Au P.K.C., Tam W.K., Li S.K.M., Leung K.C., Fung L.F., Chan M.C.Y., Luk H.M., Mak S.L.A., Leung K.Y., Tang M.H.Y., Chung B.H.Y. and Kan S.Y.A., Cost-effectiveness analysis of chromosomal microarray as a primary test for prenatal diagnosis in Hong Kong, BMC Pregnancy and Childbirth. 2020, 20. http://dx.doi.org/10.1186/s12884-020-2772-y
  • Chan H.S.S., Li R.H.W., Lee V.C.Y., Tang M.H.Y. and Ng E.H.Y., Knowledge, Attitude And Ethical Consideration Of Chinese Couples Requesting Preimplantation Genetic Testing In Hong Kong., J Obstet Gynaecol Res. 2019. http://dx.doi.org/10.1111/jog.13940

  • Cheng S.S.W., Chan Y.K., Leung K.K.P., Au P.K.C., Tam W.K., Li S.K.M., Luk H.M., Kan S.Y.A., Chung B.H.Y., Lo F.M.I. and Tang M.H.Y., Experience of chromosomal microarray applied in prenatal and postnatal settings in Hong Kong, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. http://dx.doi.org/10.1002/ajmg.c.31697

  • Mak S.L.A., Lee H., Poon C.F., Ma S.L., Ma W.L.T., Chan Y.K., Kan S.Y.A., Tang M.H.Y. and Leung K.Y., Factors associated with common and atypical chromosome abnormalities after positive combined first-trimester screening in Chinese women: a retrospective cohort study, BMC Pregnancy and Childbirth. 2019, 19. http://dx.doi.org/10.1186/s12884-019-2205-y

  • Mak S.L.A., Ma W.L.T., Chan Y.K., Kan S.Y.A., Tang M.H.Y. and Leung K.Y., Prenatal diagnosis of 5p deletion syndrome: Report of five cases, Journal of Obstetrics and Gynaecology Research. 2019, 45, 923-926. http://dx.doi.org/10.1111/jog.13911

  • So P.L., Cheng Y.K.Y., Cheuk K.Y., Chiu W.K., Mak S.L., Mok S.L., Lo T.K., Yung W.K., Lo F.M.I., Chung B.H.Y., Kan S.Y.A., Lee C.P. and Tang M.H.Y., Health professionals’ involvement and information provision in genetic counseling following prenatal diagnosis of sex chromosome aneuploidy in Hong Kong, International Journal of Gynecology & Obstetrics. 2019, 144, 314-316. http://dx.doi.org/10.1002/ijgo.12737

  • Kan S.Y.A., Lau E.T.K., So C.H., Chan W.P., Wong W.C., Lee K.C., Pertile M.D. and Tang M.H.Y., A fetus coexisting with a complete hydatidiform mole with trisomy 9 of maternal origin, Journal of Obstetrics and Gynaecology Research. 2018, 44: 955-959. http://dx.doi.org/10.1111/jog.13598 (Publication No. : 293607)

  • Leung K.C., MAK C.C.Y., Fung L.F., Wong W.H.S., TSANG H.Y., YU H.C., Pei L.C.S., Yeung K.S., Mok T.K.G., Lee C.P., Hui P.W., Tang M.H.Y., Chan Y.K., Liu A.P.Y., Yang W., Sham P.C., Kan S.Y.A. and Chung B.H.Y., Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES), BMC Medical Genomics. 2018, 11. http://dx.doi.org/10.1186/s12920-018-0409-z (Publication No. : 296434)

  • Yeung K.S., Ho S.P., Lee S.L., Kan S.Y.A., Chan Y.K., Tang M.H.Y., MAK C.C.Y., Leung K.C., So P.L., Pfundt R., Marshall C.R., Scherer S.W., Choufani S., Weksberg R. and Chung B.H.Y., Paternal uniparental disomy of chromosome 19 in a pair of monochorionic diamniotic twins with dysmorphic features and developmental delay, Journal of Medical Genetics. 2018, jmedgenet-2018-105328. http://dx.doi.org/10.1136/jmedgenet-2018-105328 (Publication No. : 286741)

  • Cheng H.Y.H., Kan A.S., Hui P.W., Lee C.P., Tang M.H.Y., Bridging the gap from prenatal karyotyping to whole-genome array comparative genomic hybridization in Hong Kong: survey on knowledge and acceptance of health-care providers and pregnant women. Arch Gynecol Obstet. 2017 Dec;296(6):1109-1116.

  • Hui A.S.Y., Au P.K.C., Ting Y.H., Kan A.S.Y., Cheng Y.K.Y., Leung A.W.K., Chan K.Y.K., Li C.K., Tang M.H.Y., Leung T.Y., First Report of a Novel Deletion Due to εγδβ-Thalassemia in a Chinese Family. Hemoglobin. 2017 May;41(3):175-179.

  • Leung W.C., Lau W.L., Lo T.K., Lau T.K., Lam Y.Y., Kan A., Chan K., Lau E.T., Tang M.H., Two IUGR foetuses with maternal uniparental disomy of chromosome 6 or UPD(6)mat. J Obstet Gynaecol. 2017 Jan;37(1):113-115.

  • Mak A.S.L., Chiu A.T.G., Leung G.K.C., Mak C.C.Y., Chu Y.W.Y., Mok G.T.K., Tang W.F., Chan K.Y.K., Tang M.H.Y., Lau Yim E.T., So K.W., Tao V.Q., Fung C.W., Wong V.C.N., Uddin M., Lee S.L., Marshall C.R., Scherer S.W., Kan A.S.Y., Chung B.H.Y., Use of clinical chromosomal microarray in Chinese Patients with autism spectrum disorder - Implications of a copy number variation Involving DPP10. Mol Autism. 2017 Jun 26;8:31.

  • So P.L., Cheng K.Y.Y., Cheuk K.Y., Chiu W.K., Mak S.L., Mok S.L., Lo T.K., Yung W.K., Lo F.M., Chung H.Y.B., Kan S.Y.A., Lee C.P., Tang H.Y.M., Parental decisions following prenatal diagnosis of sex chromosome aneuploidy in Hong Kong. J Obstet Gynaecol Res. 2017 Dec;43(12):1821-1829.

  • 林胜谋, 李之朋, 唐海燕, 余艳红. 妊娠丢失后哀伤的支持疗法 [Supporting treatment for bereavement in pregnancy loss] 中华妇产科杂志' 2017年52卷3期, 207-210页 [Zhonghua Fu Chan Ke Za Zhi. 2017 Mar, 25'52(3):207-210]

  • Au P.K.Kan A.S.Y., Tang M.H.Y., Leung K.Y.Chan K.Y.Tang T.W. and Lau E.T.K., A fetus with hemoglobin Bart’s disease due to maternal uniparental disomy for chromosome 16, Hemoglobin. 2016, 40(1): 66-69. http://dx.doi.org/10.3109/03630269.2015.1096283

  • Kou K.O.T., Poon C.F., Kwok S.L., Chan K.Y., Tang M.H.Y., Kan S.Y.A. and Leung K.Y., Effect of non-invasive prenatal testing as a contingent approach on the indications for invasive prenatal diagnosis and prenatal detection rate of Down's syndrome, Hong Kong Medical Journal. 2016, 22(3): 223-230.

  • Lee H.L.H., Mak A.S.L., Kou K.O.T., Poon C.F., Wong W.S., Chiu K.H., Au H.H.L., Chan Y.K., Kan S.Y.A., Tang M.H.Y. and Leung K.Y., An Unusual Hydrops Fetalis Associated with Compound Heterozygosity for Krüppel-like Factor 1 mutations, Hemoglobin. 2016, 40(6): 431-434.

  • Siu C.W.K., Lam C.W., Mak C.M., Lau E.T.K., Tang M.H.Y., Tang W.F., Poon-Mak R.S., Lee C.C., Hung S.F., Leung P.W., Kwong K.L., Yau E.K., Ng G.S., Fong N.C. and Chan K.Y., Diagnostic yield of array CGH in patients with autism spectrum disorder in Hong Kong, Clinical and Translational Medicine. 2016, 5.

  • Kou KO, Poon CF, Kwok SL, Chan KY, Tang MH, Kan AS, Leung KY. Effect of non-invasive prenatal testing as a contingent approach on the indications for invasive prenatal diagnosis and prenatal detection rate of Down's syndrome. Hong Kong Med J 2016 Jun;22(3):223-30.

  • Lo TK, Chan KY, Chan SS, Kan AS, Hui AP, Tang MH (2015). Pregnancy-associated plasma protein A for prediction of fetal growth restriction. Int J Gynaecol Obstet 2015 Aug;130(2):200.

  • Kan SYA, Lau ETK, Tang WF, Chan S.S.Y., Ding S.C.K., Chan YK, Lee CP, Hui P.W., Chung B.H.Y., Leung K.Y., Ma W.L.T., Leung W.C. and Tang MHY, Whole-genome Array CGH Evaluation for Replacing Prenatal Karyotyping in Hong Kong. PLOS One 2014, 9(2): e87988.

  • Tao QV, Chan YK, Chu WY, Mok TKG, Tan TY, Yang W, Lee SL, Tang WF, Tso WYW, Lau ETK, Kan SYA, Tang MHY, Lau YL and Chung BHY. The clinical impact of chromosomal microarray on paediatric care in Hong Kong. PLOS One 2014, 9(10): e:109629.

  • Ho CCA, Liu APY, Lun KS, Tang WF, Chan YK, Lau ETK, Tang MHY, Tan TY, Chung BHY. A newborn with a 790 kb chromosome 17p13.3 microduplication presenting with aortic stenosis, microcephaly and dysmorphic facial features - Is cardiac assessment necessary for all patients with 17p13.3 microduplication? European Journal of Medical Genetics. 2012;55:758-762. 

  • Kan ASY, Lee CP, Leung KY, Chan CP, Tang MHY, Chan VHY. Outcome of twin pregnancy after amniocentesis. Journal of Obstetrics and Gynaecology Research 2012;38(2): 376-382. 

  • Lau ET, Tang WF, Chan SY, Ding CK, Kan ASY, Lee CP, Hui PW, Leung KY, Ma T, Leung WC, Tang MHY. Array CGH evaluation for prenatal diagnosis in Hong Kong, Poster presentation (P1-9) in 16th International Conference on Prenatal Diagnosis and Therapy, 3-6 June, Miami, USA. Prenat Diagn 2012;32(Supp. 1):S1 . 2012. 

  • Au PK, Kwok YK, Leung KY, Tang LY, Tang MH, Lau ET. Detection of the S252W mutation in fibroblast growth factor receptor 2 (FGFR2) in fetal DNA from maternal plasma in a pregnancy affected by Apert syndrome. Prenat Diagn. 2011;31:218-20.

  • Chen EZ, Chiu RW, Sun H, Akolekar R, Chan KC, Leung TY, Jiang P, Zheng YW, Lun FM, Chan LY, Jin Y, Go AT, Lau ET, To WW, Leung WC, Tang RY, Au-Yeung SK, Lam H,  Kung YY, Zhang X, van Vugt JM, Minekawa R, Tang MH, Wang J, Oudejans CB, Lau TK,  Nicolaides KH, Lo YM. Noninvasive prenatal diagnosis of fetal trisomy 18 and trisomy 13 by maternal plasma DNA sequencing. PLoS One. 2011;6:e21791.

  • Chiu RW, Akolekar R, Zheng YW, Leung TY, Sun H, Chan KC, Lun FM, Go AT, Lau ET, To WW, Leung WC, Tang RY, Au-Yeung SK, Lam H, Kung YY, Zhang X, van Vugt JM, Minekawa R, Tang MH, Wang J, Oudejans CB, Lau TK, Nicolaides KH, Lo YM. Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study. BMJ. 2011;342:c7401.

  • Yuan Y, Leung KY, Ouyang YS, Yang F, Tang MH, Chau AK, Dai Q. Simultaneous real-time imaging of four-chamber and left ventricular outflow tract views using xPlane imaging capability of a matrix array probe. Ultrasound Obstet Gynecol.2011;37:302-9. 

  • Cheong KB, Leung KY, Li TKT, Chan HY , Lee YP , Tang MHY. Comparison of inter- and intraobserver agreement and reliability between three different types of placenta volume measurement techniques (XI VOCALTM, VOCALTM and multiplanar), and the validity in the in vitro setting. Ultrasound Obstet Gynecol. 2010 Aug;36(2):210-7. [PubMed]

  • Kan ASY, Chan HY, Lee CP, Leung KY, Chan BCP, Tang MHY. Outcome of multiple pregnancy after amniocentesis and chorionic villus sampling. Prenat Diagn 2010;30(Supp. 1):S67.

  • Leung KY, Cheong KB, Lee CP, Chan VNY, Lam YH, Tang MHY. Ultrasonographic prediction of homozygous ao-thalassemia using placental thickness, fetal cardiothoracic ratio and middle cerebral artery Doppler: alone or in combination? Ultrasound in Obstetrics & Gynecology 2010;35:149-154. (Publication No. : 180844)

  • Li HWR, Hui PW, Tang MHY, Lau ET, Yeung WSB, Ho PC, Ng EHY. Maternal serum anti-Mullerian hormone level is not superior to chronological age in predicting Down syndrome pregnancies. Prenat Diagn. 2010;30:320-4.

  • Li TKT, Leung KY, Lam YH, Tang MHY, Chan V. 2010. Haemoglobin level, proportion of Haemoglobin Bart’s and Haemoglobin Portland in fetuses affected by homozygous α0-thalassemia from 12 to 40 weeks’ gestation. Prenat Diagn 30: 1126-1130. [PubMed]

  • Chen M, Lam YH, Lee CP, Tang MH. (2004) Ultrasound screening of fetal structural abnormalities at 12 to 14 weeks in Hong Kong. Prenat Diagn. 24, 92-7.

  • Chen M, Lee CP, Leung KY, Hui PW, Tang MH. (2004) Pilot study on the midsecond trimester examination of fetal nasal bone in the Chinese population. Prenat Diagn. 24, 87-91.