Dr. Kelvin Y.K. CHAN 陳遠光博士

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Scientific Officer

BSc; PhD

location West Wing, 3rd Floor, Prenatal Diagnostic Laboratory, Tsan Yuk Hospital
phone (852)-2589-2327
fax (852)-2517-2373
email HKU Scholars Hub
Research Interests
  • Diagnostic application of molecular profiling, genotyping, and mutation detection for human diseases and abnormalities.
  • Genetic risk associations using candidate genes and genome-wide approaches;
  • Study of functions of the risk associated or contributed genetic variants;
  • Study of epigenetic events.
  • Yu P.T., Shu W., Mok S.L., Hui P.W., Chan L.W., Kwok K.Y., Chan Y.K., Lo T.K., Chung B.H.Y., Luk H.M. and Kan S.Y.A., Prenatal presentation in two fetuses with features of Beckwith Wiedemann syndrome—An unexpected diagnosis of androgenetic chimera and its clinical implications, American Journal of Medical Genetics Part A. 2022, 188A, 1562-1567.
  • YU H.C., CHAU F.T.J., Au L.K.S., Lo H.M., Yeung K.S., Fung L.F., Mak C.C.Y., CHUNG C.Y., Chan Y.K., Chung B.H.Y. and Kan S.Y.A., Evaluating the Clinical Utility of Genome Sequencing for Cytogenetically Balanced Chromosomal Abnormalities in Prenatal Diagnosis, Frontiers in Genetics. 2021, 11, 1-11. http://dx.doi.org/10.3389/fgene.2020.620162
  • Yu F.N.Y., Li E.Y.Y., Kong M.C.W., Ma T.W.L., Chan Y.K., Man E., Chung B.H.Y. and Kan S.Y.A., Increasing prenatal diagnosis of chimeras with the use of noninvasive prenatal screening: Report of two cases, Prenatal Diagnosis. 2021. http://dx.doi.org/10.1002/pd.5911
  • Seto MT, Bertoli-Avella AM, Cheung KW, Chan KY, Yeung KS, Fung JL, Beetz C, Bauer P, Luk HM, Lo IF, Lee CP, Chung BH, Kan AS. Prenatal and postnatal diagnosis of Schuurs-Hoeijmakers syndrome: Case series and review of the literature. Am J Med Genet A. 2021 Feb;185(2):384-389.
  • CHUNG C.Y., Chan Y.K., Hui P.W., Au P.K.C., Tam W.K., Li S.K.M., Leung K.C., Fung L.F., Chan M.C.Y., Luk H.M., Mak S.L.A., Leung K.Y., Tang M.H.Y., Chung B.H.Y. and Kan S.Y.A., Cost-effectiveness analysis of chromosomal microarray as a primary test for prenatal diagnosis in Hong Kong, BMC Pregnancy and Childbirth. 2020, 20. http://dx.doi.org/10.1186/s12884-020-2772-y
  • Cheng S.S.W., Chan Y.K., Leung K.K.P., Au P.K.C., Tam W.K., Li S.K.M., Luk H.M., Kan S.Y.A., Chung B.H.Y., Lo F.M.I. and Tang M.H.Y., Experience of chromosomal microarray applied in prenatal and postnatal settings in Hong Kong, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. http://dx.doi.org/10.1002/ajmg.c.31697

  • Lau W.L., Yung W.Y., Leung W.C., Kan S.Y.A., Chan Y.K., Chan K., Kan E. and Lam Y.Y., Prenatal diagnosis of familial atretic encephalocele, Ultrasound in Obstetrics & Gynecology. 2019, 54, 277-279. http://dx.doi.org/10.1002/uog.20109

  • Lo T.K., Chan Y.K., Kan S.Y.A., So P.L., Kong C.W., Mak S.L.A. and Lee C.N., Decision outcomes of women choosing extended non-invasive prenatal testing, Journal of Obstetrics and Gynaecology. 2019, 39, 733-734. http://dx.doi.org/10.1080/01443615.2018.1557123

  • Mak S.L.A., Lee H., Poon C.F., Ma S.L., Ma W.L.T., Chan Y.K., Kan S.Y.A., Tang M.H.Y. and Leung K.Y., Factors associated with common and atypical chromosome abnormalities after positive combined first-trimester screening in Chinese women: a retrospective cohort study, BMC Pregnancy and Childbirth. 2019, 19. http://dx.doi.org/10.1186/s12884-019-2205-y

  • Mak S.L.A., Ma W.L.T., Chan Y.K., Kan S.Y.A., Tang M.H.Y. and Leung K.Y., Prenatal diagnosis of 5p deletion syndrome: Report of five cases, Journal of Obstetrics and Gynaecology Research. 2019, 45, 923-926. http://dx.doi.org/10.1111/jog.13911

  • Leung K.C., Luk H.M., Tang H.M.V., Gao W., MAK C.C.Y., YU H.C., Wong W.L., Chu W.Y., Yang W., Wong W.H.S., Ma C.H., Leung A.Y.H., Jin D., Chan Y.K., Allanson J., Lo F.M.I. and Chung B.H.Y., Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies, Scientific Reports. 2018, 8: 2421. http://dx.doi.org/10.1038/s41598-018-20894-0 (Publication No. : 286747)

  • Leung K.C., MAK C.C.Y., Fung L.F., Wong W.H.S., TSANG H.Y., YU H.C., Pei L.C.S., Yeung K.S., Mok T.K.G., Lee C.P., Hui P.W., Tang M.H.Y., Chan Y.K., Liu A.P.Y., Yang W., Sham P.C., Kan S.Y.A. and Chung B.H.Y., Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES), BMC Medical Genomics. 2018, 11. http://dx.doi.org/10.1186/s12920-018-0409-z (Publication No. : 296434)

  • Lo T.K., Chan Y.K., Kan S.Y.A., So P.L., Kong C.W., Mak S.L. and Lee C.N., Effect of knowledge on women’s likely uptake of and willingness to pay for non-invasive test (NIPT), European Journal of Obstetrics & Gynecology and Reproductive Biology. 2018, 222: 183-184. http://dx.doi.org/10.1016/j.ejogrb.2018.01.005 (Publication No. : 293611)

  • TSANG H.Y., Leung K.C., Ho C.C.A., Yeung K.S., MAK C.C.Y., Pei L.C.S., YU H.C., Kan S.Y.A., Chan Y.K., Kwong K.L., Lee S.L., Yung A.W.Y., Fung C.W. and Chung B.H.Y., Exome sequencing identifies molecular diagnosis in children with drug-resistant epilepsy, Epilepsia Open. 2018. http://dx.doi.org/10.1002/epi4.12282 (Publication No. : 296420)

  • Yeung K.S., Ho S.P., Lee S.L., Kan S.Y.A., Chan Y.K., Tang M.H.Y., MAK C.C.Y., Leung K.C., So P.L., Pfundt R., Marshall C.R., Scherer S.W., Choufani S., Weksberg R. and Chung B.H.Y., Paternal uniparental disomy of chromosome 19 in a pair of monochorionic diamniotic twins with dysmorphic features and developmental delay, Journal of Medical Genetics. 2018, jmedgenet-2018-105328. http://dx.doi.org/10.1136/jmedgenet-2018-105328 (Publication No. : 286741)

  • Hui A.S.Y., Au P.K.C., Ting Y.H., Kan A.S.Y., Cheng Y.K.Y., Leung A.W.K., Chan K.Y.K., Li C.K., Tang M.H.Y., Leung T.Y., First Report of a Novel Deletion Due to εγδβ-Thalassemia in a Chinese Family. Hemoglobin. 2017 May;41(3):175-179.

  • Lo T.K., Chan K., Kan A.S., So P.L., Kong C.W., Mak S.L., Lee C.N., Study of the extent of information desired by women undergoing non-invasive prenatal testing following positive prenatal Down-syndrome screening test results. Int J Gynaecol Obstet. 2017 Jun;137(3):338-339.

  • Lo T.K., Chan K.Y., Kan A.S., So P.L., Kong C.W., Mak S.L., Lee C.N. (2017). Informed choice and decision making in women offered cell-free DNA prenatal genetic screening. Prenat Diagn. 2017 Mar;37(3):299-302.

  • Lo T.K., Chan K.Y., Kan A.S., So P.L., Kong C.W., Mak S.L., Lee C.N., Decision outcomes in women offered noninvasive prenatal test (NIPT) for positive Down screening results. J Matern Fetal Neonatal Med. 2017 Sep 19:1-3.

  • Lo T.K., Chan K.Y., Kan A.S., So P.L., Kong C.W., Mak S.L., Lee C.N., Women's stated test preference on questionnaire versus their actual choice in real clinical setting regarding non-invasive prenatal test. Eur J Obstet Gynecol Reprod Biol. 2017 Jun;213:144-145.

  • Mak A.S.L., Chiu A.T.G., Leung G.K.C., Mak C.C.Y., Chu Y.W.Y., Mok G.T.K., Tang W.F., Chan K.Y.K., Tang M.H.Y., Lau Yim E.T., So K.W., Tao V.Q., Fung C.W., Wong V.C.N., Uddin M., Lee S.L., Marshall C.R., Scherer S.W., Kan A.S.Y., Chung B.H.Y., Use of clinical chromosomal microarray in Chinese Patients with autism spectrum disorder - Implications of a copy number variation Involving DPP10. Mol Autism. 2017 Jun 26;8:31.

  • So P.L., Cheng K.Y.Y., Cheuk K.Y., Chiu W.K., Mak S.L., Mok S.L., Lo T.K., Yung W.K., Lo F.M., Chung H.Y.B., Kan S.Y.A., Lee C.P., Tang H.Y.M., Parental decisions following prenatal diagnosis of sex chromosome aneuploidy in Hong Kong. J Obstet Gynaecol Res. 2017 Dec;43(12):1821-1829.

  • Au P.K.Kan A.S.Y., Tang M.H.Y., Leung K.Y.Chan K.Y.Tang T.W. and Lau E.T.K., A fetus with hemoglobin Bart’s disease due to maternal uniparental disomy for chromosome 16, Hemoglobin. 2016, 40(1): 66-69. http://dx.doi.org/10.3109/03630269.2015.1096283

  • Lee H.L.H., Mak A.S.L., Kou K.O.T., Poon C.F., Wong W.S., Chiu K.H., Au H.H.L., Chan Y.K., Kan S.Y.A., Tang M.H.Y. and Leung K.Y., An Unusual Hydrops Fetalis Associated with Compound Heterozygosity for Krüppel-like Factor 1 mutations, Hemoglobin. 2016, 40(6): 431-434.

  • LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Wong W.L., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Sham P.C., Lau Y.L., Chung B.H.Y. and Lee S.L., CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis , Molecular Genetics & Genomic Medicine. 2016, 5(1): 40-49.

  • Kou KO, Poon CF, Kwok SL, Chan KY, Tang MH, Kan AS, Leung KY. Effect of non-invasive prenatal testing as a contingent approach on the indications for invasive prenatal diagnosis and prenatal detection rate of Down's syndrome. Hong Kong Med J 2016 Jun;22(3):223-30.

  • Lo TK, Chan KY, Chan SS, Kan AS, Hui AP, Tang MH (2015). Pregnancy-associated plasma protein A for prediction of fetal growth restriction. Int J Gynaecol Obstet 2015 Aug;130(2):200.

  • Kan SYA, Lau ETK, Tang WF, Chan S.S.Y., Ding S.C.K., Chan YK, Lee CP, Hui P.W., Chung B.H.Y., Leung K.Y., Ma W.L.T., Leung W.C. and Tang MHY, Whole-genome Array CGH Evaluation for Replacing Prenatal Karyotyping in Hong Kong. PLOS One 2014, 9(2): e87988.

  • Liu APY, Chow PC, Lee PPW, Mok TKG, Tang WF, Lau ETK, Lam STS, Chan YK, Kan SYA, Chau AKT, Cheung YF, Lau YL and Chung BHY. Under-recognition of 22q11.2 deletion in adult Chinese patients with conotruncal anomalies: Implications in transitional care. European Journal of Medical Genetics. Elsevier, 2014, 57: 306-311.

  • Tao QV, Chan YK, Chu WY, Mok TKG, Tan TY, Yang W, Lee SL, Tang WF, Tso WYW, Lau ETK, Kan SYA, Tang MHY, Lau YL and Chung BHY. The clinical impact of chromosomal microarray on paediatric care in Hong Kong. PLOS One 2014, 9(10): e:109629.

  • Ho CCA, Liu APY, Lun KS, Tang WF, Chan YK, Lau ETK, Tang MHY, Tan TY, Chung BHY. A newborn with a 790 kb chromosome 17p13.3 microduplication presenting with aortic stenosis, microcephaly and dysmorphic facial features - Is cardiac assessment necessary for all patients with 17p13.3 microduplication? European Journal of Medical Genetics. 2012;55:758-762. 

  • Long J, Cai Q, Sung H, Shi J, Zhang B, Choi JY, Wen W, Delahanty RJ, Lu W, Gao YT, Shen H, Park SK, Chen K, Shen CY, Ren Z, Haiman CA, Matsuo K, Kim MK, Khoo US, Iwasaki M, Zheng Y, Xiang YB, Gu K, Rothman N, Wang W, Hu Z, Liu Y, Yoo KY, Noh DY, Han BG, Lee MH, Zheng H, Zhang L, Wu PE, Shieh YL, Chan SY, Wang S, Xie X, Kim SW, Henderson BE, Le Marchand L, Ito H, Kasuga Y, Ahn SH, Kang HS, Chan KY, Iwata H, Tsugane S, Li C, Shu XO, Kang DH, Zheng W. Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer. PLoS Genet. 2012;8(2):e1002532.

  • Siu MK, Wong ES, Chan HY, Kong DS, Woo NW, Tam KF, Ngan HY, Chan QK, ChanDC, ChanKY, Cheung AN. Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion. Int J Cancer. 2010 Jul 1;127(1):21-31.

  • Liu SS, Chan KY, Cheung AN, Liao XY, Leung TW, Ngan HY. Expression of deltaNp73 and TAp73alpha independently associated with radiosensitivities and prognoses in cervical squamous cell carcinoma. Clin Cancer Res. 2006 Jul 1;12(13):3922-7. [PubMed]

Research Grants

  • Medical application of whole-genome technologies. S K Yee Medical Research Fund (2012) (Co-Principal Investigator) HK$5M
  • Integrated human papillomavirus analysis as adjunct for triage of atypical cervical cytology. RFCID (2008) $799k
  • Splicing variant profiling in relation to Estrogen Receptor gene expression in Chinese breast cancer. GRF (2007) (Co-Investigator) HK$883k
  • Study of human papillomavirus status in Southern Chinese women with normal cervix, precancerous cervical lesions and cervical cancers. RFCID (2006) (Co-Investigator) HK$805k
  • Promoter polymorphisms of DC-SIGN in relation to host genetic susceptibility to SARS infection. RFCID (2006) (Co-Investigator) HK$805k
  • The functional role of ICAM3 polymorphism in genetic susceptibility to SARS infection. RFCID (2005) (Co-Investigator) HK$798k
  • Gene-based and haplotype analysis of the estrogen receptor genes for breast cancer susceptibility. GRF (2005) (Co-Investigator) HK$719k
  • Stem cell related genes in gestational trophoblastic diseases. GRF (2004) (Co-Investigator) HK$940k

Professional Activities

  • 2009 - present Academic Editor of an international peer-reviewed journal PLoS One
  • 2011-present Associate Member, Hong Kong Society of Cytogenetics