Dr. Anita S.Y. KAN 簡適悠醫生

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location 2/F, East Wing, Tsan Yuk Hospital
fax (852)-2549-7375
  • Lee CL, Chen Z, Zhang Q, Guo Y, Ng VWY, Zhang B, Bai K, Ruan D, Kan ASY, Cheung KW, Mak ASL, Yeung WSB, Su R, Yang Q, Chen M, Du MR, Jian Z, Fan X, Chiu PCN. Dysregulation of the CD147 complex confers defective placental development: A pathogenesis of early-onset preeclampsia. Clin Transl Med. 2022 Jun;12(6):e826. doi: 10.1002/ctm2.826
  • BAI K., Lee C.L., Liu X., LI J., Cao D., Zhang L., Hu D., Li H., Hou Y., Xu Y., Kan S.Y.A., Cheung K.W., Ng E.H.Y., Yeung W.S.B. and Chiu C.N., Human placental exosomes induce maternal systemic immune tolerance by reprogramming circulating monocytes, Journal of Nanobiotechnology. 2022, 20.
  • Yu P.T., Shu W., Mok S.L., Hui P.W., Chan L.W., Kwok K.Y., Chan Y.K., Lo T.K., Chung B.H.Y., Luk H.M. and Kan S.Y.A., Prenatal presentation in two fetuses with features of Beckwith Wiedemann syndrome—An unexpected diagnosis of androgenetic chimera and its clinical implications, American Journal of Medical Genetics Part A. 2022, 188A, 1562-1567.
  • So PL, Hui ASY, Ma TWL, Shu W, Hui APW, Kong CW, Lo TK, Kan ANC, Kan EYL and Chong SC. Implementation of Public Funded Genome Sequencing in Evaluation of Fetal Structural Anomalies. Genes 2022, 10 November 2022; 13(11); 2088; 1. https://doi.org/10.3390/genes13112088.
  • Ng K.S.V., Lau T.K., Kan S.Y.A., Chung B.H.Y., Luk H.M., Ng W.F., Shi M., Choy K.W., Cao Y. and Leung W.C., A Fetus with Congenital Microcephaly, Microphthalmia and Cataract Was Detected with Biallelic Variants in the OCLN Gene: A Case Report, Diagnostics. 2021, 11, 1576. http://dx.doi.org/10.3390/diagnostics11091576
  • YU H.C., CHAU F.T.J., Au L.K.S., Lo H.M., Yeung K.S., Fung L.F., Mak C.C.Y., CHUNG C.Y., Chan Y.K., Chung B.H.Y. and Kan S.Y.A., Evaluating the Clinical Utility of Genome Sequencing for Cytogenetically Balanced Chromosomal Abnormalities in Prenatal Diagnosis, Frontiers in Genetics. 2021, 11, 1-11. http://dx.doi.org/10.3389/fgene.2020.620162
  • Shu W., Cheng S.S.W., Xue S., Chan L.W., Soong S.I., Kan S.Y.A., Cheung S.W.H. and Choy K.W., First Case Report of Maternal Mosaic Tetrasomy 9p Incidentally Detected on Non-Invasive Prenatal Testing, Genes. 2021, 12, 370. http://dx.doi.org/10.3390/genes12030370
  • Yu F.N.Y., Li E.Y.Y., Kong M.C.W., Ma T.W.L., Chan Y.K., Man E., Chung B.H.Y. and Kan S.Y.A., Increasing prenatal diagnosis of chimeras with the use of noninvasive prenatal screening: Report of two cases, Prenatal Diagnosis. 2021. http://dx.doi.org/10.1002/pd.5911
  • Seto MT, Bertoli-Avella AM, Cheung KW, Chan KY, Yeung KS, Fung JL, Beetz C, Bauer P, Luk HM, Lo IF, Lee CP, Chung BH, Kan AS. Prenatal and postnatal diagnosis of Schuurs-Hoeijmakers syndrome: Case series and review of the literature. Am J Med Genet A. 2021 Feb;185(2):384-389.
  • Cheung KW, Seto MTY, Kan ASY, Wong D, Kou TKO, So PL, Lau WL, Wong RMS, Lee CP, Ng EHY. Maternal and obstetric factors of hepatitis B immunisation failure in Hong Kong: a multicentre prospective study: abridged secondary publication. Hong Kong Med J. 2020 Dec;26 Suppl 6(6):24-25.
  • CHUNG C.Y., Chan Y.K., Hui P.W., Au P.K.C., Tam W.K., Li S.K.M., Leung K.C., Fung L.F., Chan M.C.Y., Luk H.M., Mak S.L.A., Leung K.Y., Tang M.H.Y., Chung B.H.Y. and Kan S.Y.A., Cost-effectiveness analysis of chromosomal microarray as a primary test for prenatal diagnosis in Hong Kong, BMC Pregnancy and Childbirth. 2020, 20. http://dx.doi.org/10.1186/s12884-020-2772-y
  • Cheng S.S.W., Chan Y.K., Leung K.K.P., Au P.K.C., Tam W.K., Li S.K.M., Luk H.M., Kan S.Y.A., Chung B.H.Y., Lo F.M.I. and Tang M.H.Y., Experience of chromosomal microarray applied in prenatal and postnatal settings in Hong Kong, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. http://dx.doi.org/10.1002/ajmg.c.31697

  • Cheung K.W., Seto T.Y.M., So P.L., Wong D., Mak S.L.A., Lau W.L., Wang W., Kan S.Y.A., Lee C.P. and Ng E.H.Y., Optimal timing of hepatitis B virus DNA quantification and clinical predictors for higher viral load during pregnancy, Acta Obstetricia et Gynecologica Scandinavica. 2019, 98, 1301-1306. http://dx.doi.org/10.1111/aogs.13631

  • Cheung K.W., Seto T.Y.M., Wong S., Mak S.L.A., So P.L., Lau W.L., Wang W., Kan S.Y.A., Lee C.P. and Ng E.H.Y., Pattern and predictors of medical care received by hepatitis B carriers during pregnancy and after delivery, Public Health. 2019, 168, 36-42. http://dx.doi.org/10.1016/j.puhe.2018.12.008

  • Cheung K.W., Seto T.Y.M., So P.L., Wong D., Mak S.L.A., Lau W.L., Lau W.L., Kan S.Y.A., Lee C.P. and Ng E.H.Y., The effect of rupture of membranes and labour on the risk of hepatitis B vertical transmission: Prospective multicentre observational study, European Journal of Obstetrics & Gynecology and Reproductive Biology. 2019, 232, 97-100. http://dx.doi.org/10.1016/j.ejogrb.2018.11.017

  • Lau W.L., Yung W.Y., Leung W.C., Kan S.Y.A., Chan Y.K., Chan K., Kan E. and Lam Y.Y., Prenatal diagnosis of familial atretic encephalocele, Ultrasound in Obstetrics & Gynecology. 2019, 54, 277-279. http://dx.doi.org/10.1002/uog.20109

  • Lo T.K., Chan Y.K., Kan S.Y.A., So P.L., Kong C.W., Mak S.L.A. and Lee C.N., Decision outcomes of women choosing extended non-invasive prenatal testing, Journal of Obstetrics and Gynaecology. 2019, 39, 733-734. http://dx.doi.org/10.1080/01443615.2018.1557123

  • Mak S.L.A., Lee H., Poon C.F., Ma S.L., Ma W.L.T., Chan Y.K., Kan S.Y.A., Tang M.H.Y. and Leung K.Y., Factors associated with common and atypical chromosome abnormalities after positive combined first-trimester screening in Chinese women: a retrospective cohort study, BMC Pregnancy and Childbirth. 2019, 19. http://dx.doi.org/10.1186/s12884-019-2205-y

  • Mak S.L.A., Ma W.L.T., Chan Y.K., Kan S.Y.A., Tang M.H.Y. and Leung K.Y., Prenatal diagnosis of 5p deletion syndrome: Report of five cases, Journal of Obstetrics and Gynaecology Research. 2019, 45, 923-926. http://dx.doi.org/10.1111/jog.13911

  • Siu K.Y., JIANG Y., WANG J., Han C.Y., Tsang B.K., Cheung A.N.Y., Ngan H.Y.S. and Chan K.K.L., Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasion and Stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 Signaling Cascades , Cancers. 2019, 11( 6 ), 813. http://dx.doi.org/10.3390/cancers11060813

  • So P.L., Cheng Y.K.Y., Cheuk K.Y., Chiu W.K., Mak S.L., Mok S.L., Lo T.K., Yung W.K., Lo F.M.I., Chung B.H.Y., Kan S.Y.A., Lee C.P. and Tang M.H.Y., Health professionals’ involvement and information provision in genetic counseling following prenatal diagnosis of sex chromosome aneuploidy in Hong Kong, International Journal of Gynecology & Obstetrics. 2019, 144, 314-316. http://dx.doi.org/10.1002/ijgo.12737

  • Cheng H.Y.H. and Kan S.Y.A., Updates on Screening for Carriers of Genetic Diseases, Journal Of Paediatrics, obstetrics & Gynaecology. 2018, 44. (Publication No. : 293605)

  • Cheung K.W., Lai W.S.C., MAK C.C.Y., Hui P.W., Chung B.H.Y. and Kan S.Y.A., A case of prenatal isolated talipes and 22q11.2 deletion syndrome-an important chromosomal disorder missed by noninvasive prenatal screening, Prenatal Diagnosis. 2018, 38(5): 376-378. http://dx.doi.org/10.1002/pd.5241 (Publication No. : 284917)

  • Cheung K.W., Seto T.Y.M., Kan S.Y.A., Jalal K., Chee W.Y.Y., Wong R.M.S., Lee C.P. and Ng E.H.Y., Immunoprophylaxis Failure of Infants Born to Hepatitis B Carrier Mothers Following Routine Vaccination, Clinical Gastroenterology and Hepatology. 2018, 16: 144-145. http://dx.doi.org/10.1016/j.cgh.2017.07.013 (Publication No. : 292449)

  • Kan S.Y.A., Lau E.T.K., So C.H., Chan W.P., Wong W.C., Lee K.C., Pertile M.D. and Tang M.H.Y., A fetus coexisting with a complete hydatidiform mole with trisomy 9 of maternal origin, Journal of Obstetrics and Gynaecology Research. 2018, 44: 955-959. http://dx.doi.org/10.1111/jog.13598 (Publication No. : 293607)

  • Leung K.C., MAK C.C.Y., Fung L.F., Wong W.H.S., TSANG H.Y., YU H.C., Pei L.C.S., Yeung K.S., Mok T.K.G., Lee C.P., Hui P.W., Tang M.H.Y., Chan Y.K., Liu A.P.Y., Yang W., Sham P.C., Kan S.Y.A. and Chung B.H.Y., Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES), BMC Medical Genomics. 2018, 11. http://dx.doi.org/10.1186/s12920-018-0409-z (Publication No. : 296434)

  • Lo T.K., Chan Y.K., Kan S.Y.A., So P.L., Kong C.W., Mak S.L. and Lee C.N., Effect of knowledge on women’s likely uptake of and willingness to pay for non-invasive test (NIPT), European Journal of Obstetrics & Gynecology and Reproductive Biology. 2018, 222: 183-184. http://dx.doi.org/10.1016/j.ejogrb.2018.01.005 (Publication No. : 293611)

  • Poon W.Y.S., Tao Q.V., Kan S.Y.A. and Chung B.H.Y., Clinical Quiz - What is the Diagnosis, Hong Kong Journal of Paediatrics (new series). 2018, 23(1): 141. (Publication No. : 284918)

  • TSANG H.Y., Leung K.C., Ho C.C.A., Yeung K.S., MAK C.C.Y., Pei L.C.S., YU H.C., Kan S.Y.A., Chan Y.K., Kwong K.L., Lee S.L., Yung A.W.Y., Fung C.W. and Chung B.H.Y., Exome sequencing identifies molecular diagnosis in children with drug-resistant epilepsy, Epilepsia Open. 2018. http://dx.doi.org/10.1002/epi4.12282 (Publication No. : 296420)

  • Yeung K.S., Ho S.P., Lee S.L., Kan S.Y.A., Chan Y.K., Tang M.H.Y., MAK C.C.Y., Leung K.C., So P.L., Pfundt R., Marshall C.R., Scherer S.W., Choufani S., Weksberg R. and Chung B.H.Y., Paternal uniparental disomy of chromosome 19 in a pair of monochorionic diamniotic twins with dysmorphic features and developmental delay, Journal of Medical Genetics. 2018, jmedgenet-2018-105328. http://dx.doi.org/10.1136/jmedgenet-2018-105328 (Publication No. : 286741)

  • Cheng H.Y.H., Kan A.S., Hui P.W., Lee C.P., Tang M.H.Y., Bridging the gap from prenatal karyotyping to whole-genome array comparative genomic hybridization in Hong Kong: survey on knowledge and acceptance of health-care providers and pregnant women. Arch Gynecol Obstet. 2017 Dec;296(6):1109-1116.

  • Cheung K.W., Seto M.T.Y., Kan A.S.Y., Wong D., Kou T.K.O., So P.L., Lau W.L., Jalal K., Chee Y.Y., Wong R.M.S., Lee C.P., Ng E.H.Y. (2017) Immunoprophylaxis failure of infants born to Hepatitis B carrier mothers following routine vaccination. Clin Gastroenterol Hepatol. 2017 Jul 18. pii: S1542-3565(17)30850-9. doi: 10.1016/j.cgh.2017.07.013

  • Hui A.S.Y., Au P.K.C., Ting Y.H., Kan A.S.Y., Cheng Y.K.Y., Leung A.W.K., Chan K.Y.K., Li C.K., Tang M.H.Y., Leung T.Y., First Report of a Novel Deletion Due to εγδβ-Thalassemia in a Chinese Family. Hemoglobin. 2017 May;41(3):175-179.

  • Lau C.T., Kan S.Y.A., Shek N.W.M., Tam P.K.H. and Wong K.K.Y., Is congenital pulmonary airway malformation really a rare disease? Result of a prospective registry with universal antenatal screening program, Pediatric Surgery International. 2017, 33(1): 105-108.

  • Leung W.C., Lau W.L., Lo T.K., Lau T.K., Lam Y.Y., Kan A., Chan K., Lau E.T., Tang M.H., Two IUGR foetuses with maternal uniparental disomy of chromosome 6 or UPD(6)mat. J Obstet Gynaecol. 2017 Jan;37(1):113-115.

  • Lo T.K., Chan K., Kan A.S., So P.L., Kong C.W., Mak S.L., Lee C.N., Study of the extent of information desired by women undergoing non-invasive prenatal testing following positive prenatal Down-syndrome screening test results. Int J Gynaecol Obstet. 2017 Jun;137(3):338-339.

  • Lo T.K., Chan K.Y., Kan A.S., So P.L., Kong C.W., Mak S.L., Lee C.N. (2017). Informed choice and decision making in women offered cell-free DNA prenatal genetic screening. Prenat Diagn. 2017 Mar;37(3):299-302.

  • Lo T.K., Chan K.Y., Kan A.S., So P.L., Kong C.W., Mak S.L., Lee C.N., Decision outcomes in women offered noninvasive prenatal test (NIPT) for positive Down screening results. J Matern Fetal Neonatal Med. 2017 Sep 19:1-3.

  • Lo T.K., Chan K.Y., Kan A.S., So P.L., Kong C.W., Mak S.L., Lee C.N., Women's stated test preference on questionnaire versus their actual choice in real clinical setting regarding non-invasive prenatal test. Eur J Obstet Gynecol Reprod Biol. 2017 Jun;213:144-145.

  • So P.L., Cheng K.Y.Y., Cheuk K.Y., Chiu W.K., Mak S.L., Mok S.L., Lo T.K., Yung W.K., Lo F.M., Chung H.Y.B., Kan S.Y.A., Lee C.P., Tang H.Y.M., Parental decisions following prenatal diagnosis of sex chromosome aneuploidy in Hong Kong. J Obstet Gynaecol Res. 2017 Dec;43(12):1821-1829.

  • Au P.K.Kan A.S.Y., Tang M.H.Y., Leung K.Y.Chan K.Y.Tang T.W. and Lau E.T.K., A fetus with hemoglobin Bart’s disease due to maternal uniparental disomy for chromosome 16, Hemoglobin. 2016, 40(1): 66-69. http://dx.doi.org/10.3109/03630269.2015.1096283

  • Chiu T.A., Chu W.Y., Kan S.Y.A. and Chung B.H.Y., What is the Diagnosis?, Hong Kong Journal of Paediatrics (new series). Medcom Limited, 2016, 21(4): 298,311-314.

  • Kou K.O.T., Poon C.F., Kwok S.L., Chan K.Y., Tang M.H.Y., Kan S.Y.A. and Leung K.Y., Effect of non-invasive prenatal testing as a contingent approach on the indications for invasive prenatal diagnosis and prenatal detection rate of Down's syndrome, Hong Kong Medical Journal. 2016, 22(3): 223-230.

  • Lee H.L.H., Mak A.S.L., Kou K.O.T., Poon C.F., Wong W.S., Chiu K.H., Au H.H.L., Chan Y.K., Kan S.Y.A., Tang M.H.Y. and Leung K.Y., An Unusual Hydrops Fetalis Associated with Compound Heterozygosity for Krüppel-like Factor 1 mutations, Hemoglobin. 2016, 40(6): 431-434.

  • Kou KO, Poon CF, Kwok SL, Chan KY, Tang MH, Kan AS, Leung KY. Effect of non-invasive prenatal testing as a contingent approach on the indications for invasive prenatal diagnosis and prenatal detection rate of Down's syndrome. Hong Kong Med J 2016 Jun;22(3):223-30.

  • Lo TK, Chan KY, Chan SS, Kan AS, Hui AP, Tang MH (2015). Pregnancy-associated plasma protein A for prediction of fetal growth restriction. Int J Gynaecol Obstet 2015 Aug;130(2):200.

  • Kan SYA, Lau ETK, Tang WF, Chan S.S.Y., Ding S.C.K., Chan YK, Lee CP, Hui P.W., Chung B.H.Y., Leung K.Y., Ma W.L.T., Leung W.C. and Tang MHY, Whole-genome Array CGH Evaluation for Replacing Prenatal Karyotyping in Hong Kong. PLOS One 2014, 9(2): e87988.

  • Liu APY, Chow PC, Lee PPW, Mok TKG, Tang WF, Lau ETK, Lam STS, Chan YK, Kan SYA, Chau AKT, Cheung YF, Lau YL and Chung BHY. Under-recognition of 22q11.2 deletion in adult Chinese patients with conotruncal anomalies: Implications in transitional care. European Journal of Medical Genetics. Elsevier, 2014, 57: 306-311.

  • Tao QV, Chan YK, Chu WY, Mok TKG, Tan TY, Yang W, Lee SL, Tang WF, Tso WYW, Lau ETK, Kan SYA, Tang MHY, Lau YL and Chung BHY. The clinical impact of chromosomal microarray on paediatric care in Hong Kong. PLOS One 2014, 9(10): e:109629.

  • Kan ASY, Lee CP, Leung KY, Chan CP, Tang MHY, Chan VHY. Outcome of twin pregnancy after amniocentesis. Journal of Obstetrics and Gynaecology Research 2012;38(2): 376-382. 

  • Lau ET, Tang WF, Chan SY, Ding CK, Kan ASY, Lee CP, Hui PW, Leung KY, Ma T, Leung WC, Tang MHY. Array CGH evaluation for prenatal diagnosis in Hong Kong, Poster presentation (P1-9) in 16th International Conference on Prenatal Diagnosis and Therapy, 3-6 June, Miami, USA. Prenat Diagn 2012;32(Supp. 1):S1 . 2012. 

  • Cheung E, Tsang S, Bow C, Soong C, Yeung S, Loong C, Cheung CL, Kan ASY, Lo S, Tam Sy, Tang GWK, Kung AWC. Bone loss during menopausal transition among southern Chinese Women. Maturitas 2011;69:50-56. [Medline]

  • Kan ASY, Chan HY, Lee CP, Leung KY, Chan BCP, Tang MHY. Outcome of multiple pregnancy after amniocentesis and chorionic villus sampling. Prenat Diagn 2010;30(Supp. 1):S67.

  • Kan AS, Ng EH, Ho PC. (2004) The role and comparison of two techniques of paracervical block for pain relief during suction evacuation for first-trimester pregnancy termination. Contraception. 70, 159-63.

Professional Activities

  • 2008 – present, Council Member, Osteoporosis Society of Hong Kong
  • 2012 – 2014 , Honorary Secretary, Osteoporosis Society of Hong Kong