Dr. Andy C.H. CHEN 陳進鏗博士
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Research Assistant Professor BSc; MPhil, PhD (HKU) |
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https://orcid.org/0000-0002-7065-3192 |
Research Interests
- Growth factors and extracellular matrix proteins on growth and pluripotency of embryonic stem cells
- microRNAs and epigenetic regulators on reprogramming of somatic cells
- Developmental origins of health and disease
- Trophoblast development
Publications
2024
- Wen Huang, Andy Chun Hang Chen, Xujin Wei, Sze Wan Fong, William Shu Biu Yeung & Yin Lau Lee. Uncovering the role of TET2-mediated ENPEP activation in trophoblast cell fate determination. Cell. Mol. Life Sci. 81, 270 (2024). https://doi.org/10.1007/s00018-024-05306-z
2023
- Lee C.Y.L., Ruan H., Lee K.C., Fong S.W., YUE C., Chen C.H., Lee C.K.F., Lam M.T., Yeung W.S.B., Li R.H.W. and Ng E.H.Y., Attachment of trophoblastic spheroid onto endometrial epithelial cells predicts cumulative livebirth of women aged 35 or over, Fertility and Sterility. 2023.
- QIU Q., LI Y., Fong S.W., Lee K.C., Chen C.H., Ruan H., Lee C.K.F., Li R.H.W., Ng E.H.Y., Yeung W.S.B. and Lee C.Y.L., Endometrial stromal cells from women with repeated implantation failure display impaired invasion towards trophoblastic spheroids, Reproduction. 2023
- Lee YL, Chen ACH, Yeung WSB (2023). “Reproductive tract development and gametogenesis Chapter 9: Interaction of Sperm and Embryo with the Female Reproductive Tract, Human Reproductive and Prenatal Genetics, 2nd Edition, edited by Peter Leung and Jie Qiao. Elsevier. ISBN: 9780323913805.
2021
- Chen C.H., Peng Q., Fong S.W., Lee K.C., Yeung W.S.B. and Lee C.Y.L., DNA Damage Response and Cell Cycle Regulation in Pluripotent Stem Cells, Genes. 2021, 12, 1548. http://dx.doi.org/10.3390/genes12101548
- Chen C.H., HUANG W., Fong S.W., Chan C., Lee K.C., Yeung W.S.B. and Lee C.Y.L., Hyperglycemia Altered DNA Methylation Status and Impaired Pancreatic Differentiation from Embryonic Stem Cells, International Journal of Molecular Sciences. 2021, 22, 10729. http://dx.doi.org/10.3390/ijms221910729
2020
- Chen AC, Lee KF, Yeung WSB, Lee YL. Human embryonic stem cells as an in vitro model for studying developmental origins of type 2 diabetes. World J Stem Cells. 2020 Aug 26;12(8):761-775. doi: 10.4252/wjsc.v12.i8.761. PMID: 32952857; PMCID: PMC7477660.
- Kubi JA, Chen ACH, Fong SW, Lai KP, Wong CKC, Yeung WSB, Lee KF, Lee YL. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the differentiation of embryonic stem cells towards pancreatic lineage and pancreatic beta cell function. Environ Int. 2019 Sep;130:104885. doi: 10.1016/j.envint.2019.05.079. Epub 2019 Jun 10. PMID: 31195220.
- Chen C.H., PENG Q., Fong S.W., Yeung W.S.B. and Lee C.Y.L., Sirt1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming, Aging. 2020. http://dx.doi.org/10.18632/aging.103090
2019
Gao X, Nowak-Imialek M, Chen X, Chen D, Herrmann D, Ruan D, Chen ACH, Eckersley-Maslin MA, Ahmad S, Lee YL, Kobayashi T, Ryan D, Zhong J, Zhu J, Wu J, Lan G, Petkov S, Yang J, Antunes L, Campos LS, Fu B, Wang S, Yong Y, Wang X, Xue SG, Ge L, Liu Z, Huang Y, Nie T, Li P, Wu D, Pei D, Zhang Y, Lu L, Yang F, Kimber SJ, Reik W, Zou X, Shang Z, Lai L, Surani A, Tam PPL, Ahmed A, Yeung WSB, Teichmann SA, Niemann H, and Liu P (2019). Establishment of porcine and human expanded potential stem cells. Nature Cell Biology. 21(6): p. 687-699
KUBI J.A., Chen C.H., Fong S.W., Lai K.P., Wong C.K.C., Yeung W.S.B., Lee C.K.F. and Lee C.Y.L., Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the differentiation of embryonic stem cells towards pancreatic lineage and pancreatic beta cell function, Environment International. 2019, 130, 104885. http://dx.doi.org/10.1016/j.envint.2019.05.079
2018
Lai K.P., Li J.W., Chan T.F., Chen C.H., Lee C.Y.L., Yeung W.S.B. and Wong C.K., Transcriptomic and methylomic analysis reveal the toxicological effect of 2,3,7,8-Tetrachlorodibenzodioxin on human embryonic stem cell. , Chemosphere. Elsevier Ltd, 2018, 206, 663-673. http://dx.doi.org/10.1016/j.chemosphere.2018.05.058
Peng Q./., YUE C., Chen C.H., Lee K.C., Fong S.W., Yeung W.S.B. and Lee C.Y.L., Connexin 43 is involved in early differentiation of human embryonic stem cells, Differentiation. 2018, 105, 33-44. http://dx.doi.org/10.1016/j.diff.2018.12.003
2017
Chen C.H., Lee C.Y.L., Fong S.W., Wong C.C.Y., Ng E.H.Y. and Yeung W.S.B., Hyperglycemia impedes definitive endoderm differentiation of human embryonic stem cells by modulating histone methylation patterns, Cell and Tissue Research. 2017, 2017 Jun;368(3):563-578.
